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Prior to use, a translucent to clear secondary protective liner card that rests over the pigmented film is removed also, a protective release liner of silicone coated polyester film that covers the adhesive layer is removed.Ĭlonidine transdermal system is programmed to release clonidine at an approximately constant rate for 7 days.
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#Half life 1 patch skin#
Proceeding from the visible surface towards the surface attached to the skin, there are four consecutive layers: 1) a backing layer of pigmented polyethylene/aluminum/polyester film 2) a drug reservoir of clonidine, acrylic adhesive 3) an ethylene vinyl acetate membrane that controls the rate of delivery of clonidine from the system to the skin surface 4) an adhesive formulation of clonidine and acrylic adhesive. The composition per unit area is the same for all three doses. The system areas are 4.1 cm 2 (0.1 mg per day for one week), 8.2 cm 2 (0.2 mg per day for one week) and 12.3 cm 2 (0.3 mg per day for one week) and the amount of drug released is directly proportional to the area (see Release Rate Concept). System Structure and ComponentsĬlonidine Transdermal System, USP is a multi-layered film, 0.2 mm thick, containing clonidine as the active agent.